ALLOSTERIC MODULATORS OF THE MU OPIOID RECEPTOR

Disclosed herein are compounds which act as positive allosteric modulators and silent allosteric modulators of the mu opioid receptor. Methods for making and using the allosteric modulators disclosed herein are also provided. L'invention concerne des composés agissant en tant que modulateurs al...

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Bibliographic Details
Main Authors VANHEYST, Michael, ROWLEY, Elizabeth Gerig, HARVEY, James S, LAMARQUE-LACOSTE, Christophe, AUSTIN, Joel Francis
Format Patent
LanguageEnglish
French
Published 30.01.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed herein are compounds which act as positive allosteric modulators and silent allosteric modulators of the mu opioid receptor. Methods for making and using the allosteric modulators disclosed herein are also provided. L'invention concerne des composés agissant en tant que modulateurs allostériques positifs et modulateurs allostériques silencieux du récepteur opioïde mu. L'invention concerne également des procédés de préparation et d'utilisation des modulateurs allostériques selon l'invention.
Bibliography:Application Number: WO2018US61866