ALKYNYL (HETERO) AROMATIC RING COMPOUNDS USED FOR INHIBITING PROTEIN KINASE ACTIVITY

Disclosed are alkynyl (hetero) aromatic ring compounds that inhibit protein tyrosine kinases, pharmaceutical compositions comprising same, preparations therefor and uses thereof. Specifically, disclosed are an alkynyl (hetero) aromatic ring compound represented by formula (I), and a pharmaceutically...

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Bibliographic Details
Main Authors WANG, Yihan, AI, Yixin, XING, Qingfeng
Format Patent
LanguageChinese
English
French
Published 23.01.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are alkynyl (hetero) aromatic ring compounds that inhibit protein tyrosine kinases, pharmaceutical compositions comprising same, preparations therefor and uses thereof. Specifically, disclosed are an alkynyl (hetero) aromatic ring compound represented by formula (I), and a pharmaceutically acceptable salt, a stereoisomer, a solvate, a hydrate, a crystal form, a prodrug or an isotope variant thereof. The disclosed compounds may be used in the treatment and/or prevention of diseases associated with protein tyrosine kinase, such as in preventing tumors. L'invention concerne des composés alcynyle cycliques (hétéro)aromatiques qui inhibent des protéines tyrosine kinases, des compositions pharmaceutiques les comprenant, des préparations de ceux-ci et des utilisations associées. Plus particulièrement, l'invention concerne un composé alcynyle cyclique (hétéro)aromatique représenté par la formule (I), et un sel pharmaceutiquement acceptable, un stéréoisomère, un solvate, un hydrate, une forme cristalline, un
Bibliography:Application Number: WO2019CN96062