NOVEL METHOD TO ENGINEER TRANSLANTABLE HUMAN TISSUES

This disclosure relates to methods, polynucleotides, vectors, viral particles, cells, and systems or the engineering of human tissues. One aspect of the disclosure relates to using lineage-specific miRNA binding molecules to bias tissue lineage. Another aspect of the disclosure relates to using line...

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Bibliographic Details
Main Authors WU, Yan, MALI, Prashant, PAREKH, Udit, DAILAMY, Amir, MCDONALD, Daniella, HU, Michael, ZHANG, Kun
Format Patent
LanguageEnglish
French
Published 09.01.2020
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:This disclosure relates to methods, polynucleotides, vectors, viral particles, cells, and systems or the engineering of human tissues. One aspect of the disclosure relates to using lineage-specific miRNA binding molecules to bias tissue lineage. Another aspect of the disclosure relates to using lineage-specific transcription factor overexpression to bias tissue lineage. La présente invention concerne des procédés, des polynucléotides, des vecteurs, des particules virales, des cellules et des systèmes ou l'ingénierie de tissus humains. Un aspect de l'invention concerne l'utilisation de molécules de liaison de miARN spécifiques de lignée pour influencer une lignée de tissu. Un autre aspect de l'invention concerne l'utilisation d'une surexpression d'un facteur de transcription spécifique de lignée pour influencer une lignée de tissu.
Bibliography:Application Number: WO2019US40590