METHODS OF INHIBITING PROLIFERATIVE CELLS

• Main Authors: BELMONT, Lisa, KATEGAYA, Lorn, HATA, Yujiro, HAGER, Jeff
• Format: Patent
• Language: English; French
• Published: 19.12.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention provides methods of negatively modulating the Werner protein (WRN) to inhibit proliferative cells characterized by high microsatellite instability (MSI-H), for example to treat proliferative diseases (such as cancer) characterized by high MSI (MSI-H). Further provided are compositions used in such methods. La présente invention concerne des procédés de modulation négative de la protéine Werner (WRN) pour inhiber des cellules prolifératives caractérisées par une instabilité des microsatellites élevée (MSI-H), par exemple pour traiter des maladies prolifératives (comme le cancer) caractérisées par une MSI élevée (MSI-H). L'invention concerne en outre des compositions utilisées dans de tels procédés.