INDAZOLE CONTAINING MACROCYCLES AND THERAPEUTIC USES THEREOF
Indazole macrocycle compounds of formula (I) for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole macrocycle compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway sign...
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Main Authors | , , , |
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Format | Patent |
Language | English French |
Published |
19.12.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Indazole macrocycle compounds of formula (I) for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole macrocycle compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states. Formula (I)
L'invention concerne des composés d'indazole macrocycliques de formule (I) destinés à traiter diverses maladies et pathologies. Plus particulièrement, la présente invention concerne l'utilisation d'un composé d'indazole macrocyclique ou d'analogues de celui-ci, dans le traitement de troubles caractérisés par l'activation de la signalisation de la voie Wnt (par exemple, un cancer, une prolifération cellulaire anormale, l'angiogenèse, des troubles fibrotiques, des maladies osseuses ou cartilagineuses et l'arthrose), la modulation d'événements cellulaires à médiation par la signalisation de la voie Wnt, ainsi que de maladies génétiques et d'états pathologiques/troubles/maladies neurologiques dus à des mutations ou à un dérèglement de la voie Wnt et/ou d'une ou de plusieurs composantes de la signalisation Wnt. L'invention concerne également des méthodes de traitement d'états pathologiques associés à Wnt. Formule (I) |
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Bibliography: | Application Number: WO2019US37024 |