NOVEL PEPTIDE, CHIMERIC ANTIGEN RECEPTOR COMPRISING SAME, AND IMMUNE CELLS EXPRESSING SAME

• Main Authors: JUNG, Mi Young, LEE, Eun Sol, WON, Sung Yong, KIM, Han Sol, CHOI, Eun Ji, LIM, Ho Yong, GWON, Su Hyun, CHO, Sung Yoo, HWANG, Yu Kyeong
• Format: Patent
• Language: English; French; Korean
• Published: 19.12.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a novel peptide and a chimeric antigen receptor comprising same. The present invention relates to a chimeric antigen receptor (CAR) which has an intracellular signaling domain including part or entirety of the novel peptide and thus exhibits an excellent effect of augmenting the anticancer activity of immune cells and to immune cells expressing same. La présente invention concerne un nouveau peptide et un récepteur antigénique chimérique le comprenant. La présente invention concerne un récepteur antigénique chimérique (CAR) qui a un domaine de signalisation intracellulaire comprenant une partie ou la totalité du nouveau peptide et qui présente ainsi un excellent effet d'augmentation de l'activité anticancéreuse de cellules immunitaires ainsi que des cellules immunitaires les exprimant. 본 발명은 신규한 펩티드 및 이를 포함하는 키메라 항원 수용체에 관한 것으로서, 신규한 펩티드의 전체 또는 일부를 포함하는 세포내 신호전달 도메인 (intracellular signaling domain)을 포함함으로써 면역세포의 항암 활성 증대 효과가 우수한 키메라 항원 수용체 (chimeric antigen receptor, CAR) 및 이를 발현하는 면역세포에 관한 것이다.