IMIDAZOPYRAZINE INHIBITORS OF INTERLEUKIN-2-INDUCIBLE T-CELL KINASE

In some embodiments, the invention relates to an interleukin-2- inducible T-cell kinase (ITK) inhibitor of formula (I) or a pharmaceutically acceptable salt thereof, or to pharmaceutical compositions comprising these compounds and to their use in the treatment of ITK mediated disorders. Dans certain...

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Main Authors DE ZWART, Edwin, VERKAIK, Saskia, HOOGENBOOM, Niels, BARF, Tjeerd, COVEY, Todd, DEMONT, Dennis, KAPTEIN, Allard
Format Patent
LanguageEnglish
French
Published 19.12.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:In some embodiments, the invention relates to an interleukin-2- inducible T-cell kinase (ITK) inhibitor of formula (I) or a pharmaceutically acceptable salt thereof, or to pharmaceutical compositions comprising these compounds and to their use in the treatment of ITK mediated disorders. Dans certains modes de réalisation, l'invention concerne un inhibiteur de kinase de lymphocytes T inductible par l'interleukine-2 (kinase ITK) de formule (I) ou un sel pharmaceutiquement acceptable de celui-ci, ou des compositions pharmaceutiques comprenant ces composés et leur utilisation dans le traitement de troubles médiés par la kinase ITK. (I)
Bibliography:Application Number: WO2019IB54971