NUCLEIC ACID APTAMERS TARGETING LYMPHOCYTE ACTIVATION GENE 3 (LAG-3) AND USES THEREOF

Nucleic acid aptamers capable of binding to lymphocyte activation gene 3 (LAG-3) and uses thereof for modulating immune responses. Such aptamers may comprise a G-rich motif, for example, GX1GGGX2GGTX3A (SEQ ID No: 1), in which each of X1 and X2 are independently G, C, or absent, and X3 is T or C, or...

Full description

Saved in:
Bibliographic Details
Main Authors CHIANG, Chien-Hao, CHANG, Yi-Chung, KAO, Yi-Wei
Format Patent
LanguageEnglish
French
Published 19.12.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
COMPOSITIONS THEREOF
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
Online AccessGet full text

Cover

More Information
Summary:Nucleic acid aptamers capable of binding to lymphocyte activation gene 3 (LAG-3) and uses thereof for modulating immune responses. Such aptamers may comprise a G-rich motif, for example, GX1GGGX2GGTX3A (SEQ ID No: 1), in which each of X1 and X2 are independently G, C, or absent, and X3 is T or C, or L- (G)n-L', in which n is an integer of 5-9 inclusive, and L and L'are nucleotide segments having complementary sequences. Also provided herein are multimeric nucleic acid aptamers containing a backbone moiety, which comprises a palindromic sequence. L'invention concerne des aptamères d'acide nucléique capables de se lier au gène 3 d'activation des lymphocytes (LAG-3) et leurs utilisations pour moduler des réponses immunitaires. De tels aptamères peuvent comprendre un motif riche en G, par exemple GX 1GGGX 2GGTX 3A (N° d'ID de SÉQ. : 1), dans lequel chacun des X 1 et X 2 est indépendamment G, C, ou absent, et X 3 est T ou C ou L- (G) n-L', où n est un nombre entier de 5 à 9 inclus, et L et L' sont des segments de nucléotides ayant des séquences complémentaires. L'invention concerne également des aptamères d'acides nucléiques multimères contenant un groupe caractéristique de squelette, qui comprend une séquence palindromique.
Bibliography:Application Number: WO2019CN90832