NAV1.7 MONOCLONAL ANTIBODY

• Main Authors: KODAMA Mai, MIYAUCHI Tsuguo, TAKAHASHI Tatsuya, ONODA Junji, NAKAMURA Etsuo, KASAI Erika, YONEDA Sosuke, ASAKI Toshiyuki
• Format: Patent
• Language: English; French; Japanese
• Published: 05.12.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The purpose of the present invention is to provide a novel Nav1.7 monoclonal antibody. Disclosed is a Nav1.7 monoclonal antibody having six specific CDRs (heavy-chain CDR1 through CDR3 and light-chain CDR1 through CDR3) or a specific heavy-chain variable region/light-chain variable region, or an antibody fragment of the Nav1.7 monoclonal antibody. The monoclonal antibody, etc., can be used in the treatment or prevention of pain, pruritus, etc. L'objet de la présente invention est de fournir un nouvel anticorps monoclonal Nav1.7. L'invention concerne un anticorps monoclonal Nav1.7 ayant six CDR spécifiques (chaîne Lourde CDR1 à CDR3 et chaîne légère CDR1 à CDR3) ou une région variable de chaîne lourde/région variable de chaîne lègère spécifique, ou un fragment d'anticorps de l'anticorps monoclonal Nav1.7. L'anticorps monoclonal, etc, peut être utilisé dans le traitement ou la prévention de la douleur, du prurit, etc. 本発明の目的は新規のＮａｖ１．７モノクローナル抗体を提供することにある。特定の６つのＣＤＲ（重鎖のＣＤＲ１～ＣＤＲ３及び軽鎖のＣＤＲ１～ＣＤＲ３）又は特定の重鎖可変領域／軽鎖可変領域を有するＮａｖ１．７モノクローナル抗体又はその抗体断片を開示する。該モノクローナル抗体等は、疼痛、掻痒等の治療又は予防に用いることができる。