NOVEL SUBSTITUTED RIG-I AGONISTS: COMPOSITIONS AND METHODS THEREOF
This invention provides compositions, compounds, and uses thereof, wherein said compounds comprise a single strand oligonucleotide that may form a short oligonucleotide hairpin or stem loop molecule with self complementary base pairing of less than 12 base pairs that bind to RIG-I and activate the R...
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| Main Authors | , , , , , |
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| Format | Patent |
| Language | English French |
| Published |
24.10.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | This invention provides compositions, compounds, and uses thereof, wherein said compounds comprise a single strand oligonucleotide that may form a short oligonucleotide hairpin or stem loop molecule with self complementary base pairing of less than 12 base pairs that bind to RIG-I and activate the RIG-I pathway.
La présente invention concerne des compositions, des composés et leurs utilisations, lesdits composés comprenant un oligonucléotide à simple brin qui peut former un court oligonucléotide en épingle à cheveux ou une molécule à tige-boucle avec un appariement de bases auto-complémentaire inférieur à 12 paires de bases qui se lient à RIG-I et activent la voie RIG-I. |
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| AbstractList | This invention provides compositions, compounds, and uses thereof, wherein said compounds comprise a single strand oligonucleotide that may form a short oligonucleotide hairpin or stem loop molecule with self complementary base pairing of less than 12 base pairs that bind to RIG-I and activate the RIG-I pathway.
La présente invention concerne des compositions, des composés et leurs utilisations, lesdits composés comprenant un oligonucléotide à simple brin qui peut former un court oligonucléotide en épingle à cheveux ou une molécule à tige-boucle avec un appariement de bases auto-complémentaire inférieur à 12 paires de bases qui se lient à RIG-I et activent la voie RIG-I. |
| Author | CHANG, Wonsuk TRUONG, Quang WANG, Hongwu WASSERMANN, Anne Mai PARISH, Craig SIU, Tony |
| Author_xml | – fullname: PARISH, Craig – fullname: WASSERMANN, Anne Mai – fullname: TRUONG, Quang – fullname: WANG, Hongwu – fullname: CHANG, Wonsuk – fullname: SIU, Tony |
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| DocumentTitleAlternate | NOUVEAUX AGONISTES DE RIG-I SUBSTITUÉS : COMPOSITIONS ET MÉTHODES ASSOCIÉES |
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| RelatedCompanies | TRUONG, Quang, T CHANG, Wonsuk PARISH, Craig, A WANG, Hongwu WASSERMANN, Anne Mai MERCK SHARP & DOHME CORP SIU, Tony |
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| Snippet | This invention provides compositions, compounds, and uses thereof, wherein said compounds comprise a single strand oligonucleotide that may form a short... |
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| SubjectTerms | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| Title | NOVEL SUBSTITUTED RIG-I AGONISTS: COMPOSITIONS AND METHODS THEREOF |
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