NOVEL SUBSTITUTED RIG-I AGONISTS: COMPOSITIONS AND METHODS THEREOF

This invention provides compositions, compounds, and uses thereof, wherein said compounds comprise a single strand oligonucleotide that may form a short oligonucleotide hairpin or stem loop molecule with self complementary base pairing of less than 12 base pairs that bind to RIG-I and activate the R...

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Bibliographic Details
Main Authors PARISH, Craig, WASSERMANN, Anne Mai, TRUONG, Quang, WANG, Hongwu, CHANG, Wonsuk, SIU, Tony
Format Patent
LanguageEnglish
French
Published 24.10.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:This invention provides compositions, compounds, and uses thereof, wherein said compounds comprise a single strand oligonucleotide that may form a short oligonucleotide hairpin or stem loop molecule with self complementary base pairing of less than 12 base pairs that bind to RIG-I and activate the RIG-I pathway. La présente invention concerne des compositions, des composés et leurs utilisations, lesdits composés comprenant un oligonucléotide à simple brin qui peut former un court oligonucléotide en épingle à cheveux ou une molécule à tige-boucle avec un appariement de bases auto-complémentaire inférieur à 12 paires de bases qui se lient à RIG-I et activent la voie RIG-I.
Bibliography:Application Number: WO2019US27423