SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES

The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative dis...

Full description

Saved in:
Bibliographic Details
Main Authors NIKULENKOV, Fedor, HAVEL, Stepan, VSIANSKY, Vit, KREJCI, Lumir, CARBAIN, Benoit, PARUCH, Kamil
Format Patent
LanguageEnglish
French
Published 24.10.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases. L'invention concerne des composés représentés par la formule structurelle (1) : dans laquelle R1, R2, R3, R4, R5, R6 sont tels que définis dans les revendications. Les composés sont des inhibiteurs de nucléases, et sont utiles en particulier dans une méthode de traitement et/ou de prévention de maladies prolifératives, de maladies neurodégénératives, et d'autres maladies associées à l'instabilité génomique.
Bibliography:Application Number: WO2019EP59693