PACKAGING OLIGONUCLEOTIDES INTO VIRUS-LIKE PARTICLES

• Main Authors: HENNECKE, Frank, WALTERS, Evan David
• Format: Patent
• Language: English; French
• Published: 17.10.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to processes for producing compositions comprising (i) a virus-like particle of an RNA bacteriophage, and (ii) aggregated oligonucleotides, wherein said aggregated oligonucleotides are packaged into said virus-like particle. The invention further provides processes for producing nucleotide compositions comprising aggregated oligonucleotides suitable for use in the aforementioned processes before. Moreover, the invention further provides nucleotide compositions comprising aggregated oligonucleotides. Furthermore, the invention further provides compositions comprising (i) a virus-like particle of an RNA bacteriophage, and (ii) aggregated oligonucleotides, wherein said aggregated oligonucleotides are packaged into said virus-like particle. La présente invention concerne des procédés de production de compositions comprenant (i) une particule pseudovirale d'un bactériophage à ARN et (ii) des oligonucléotides agrégés, lesdits oligonucléotides agrégés étant encapsulés dans ladite particule pseudovirale. L'invention concerne en outre des procédés de production de compositions de nucléotides comprenant des oligonucléotides agrégés appropriés pour une utilisation dans les procédés susmentionnés. De plus, l'invention concerne en outre des compositions de nucléotides comprenant les oligonucléotides agrégés. De plus, l'invention concerne en outre des compositions comprenant (i) une particule pseudovirale d'un bactériophage à ARN et (ii) des oligonucléotides agrégés, lesdits oligonucléotides agrégés étant encapsulés dans ladite particule pseudovirale.