A METHOD OF MODULATING THE RNA METHYLATION

Methods and compounds are reported that specifically modulate RNA methylation by activation of the RNA methyltransferase complex METTL3/METTL14. In some embodiments, the compound has binding and/or activation for a METTL3/METTL14/WTAP complex. L'invention concerne des procédés et des composés q...

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Bibliographic Details
Main Authors BLOKHINA, Daria, SELBERG, Simona, KANKURI, Esko, KARELSON, Mati
Format Patent
LanguageEnglish
French
Published 17.10.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
VINEGAR
WINE
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Summary:Methods and compounds are reported that specifically modulate RNA methylation by activation of the RNA methyltransferase complex METTL3/METTL14. In some embodiments, the compound has binding and/or activation for a METTL3/METTL14/WTAP complex. L'invention concerne des procédés et des composés qui modulent spécifiquement la méthylation de l'ARN par activation du complexe ARN méthyltransférase METTL3/METTL14. Dans certains modes de réalisation, le composé se lie à et/ou active un complexe METTL3/METTL14/WTAP.
Bibliography:Application Number: WO2018EP59284