BISPECIFIC POLYPEPTIDE STRUCTURALLY BASED ON UTEROGLOBIN

• Main Authors: ISE, Tomoko, TSUMOTO, Kohei, INOUE, Tsuyoshi, NAGATA, Satoshi, AKIBA, Hiroki, MIZUGUCHI, Kenji, NAGAO, Chioko, NIIYAMA, Mayumi, AFANASEVA, Arina, KAMADA, Haruhiko, FUKUDA, Yohta, ABE, Yasuhiro
• Format: Patent
• Language: English; French; Japanese
• Published: 19.09.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided is a low-molecular weight bispecific polypeptide. A heterodimer uteroglobin is prepared by modifying, to a low-molecular weight uteroglobin, an Fc region in a bispecific antibody constructed from a natural antibody, and causing a uteroglobin monomer to be mutated, and a bispecific polypeptide is constructed by using the same. L'invention concerne un polypeptide bispécifique de faible masse moléculaire. Une uteroglobine hétérodimère est préparée en modifiant, pour former une utéroglobine de faible masse moléculaire, une région Fc d'un anticorps bispécifique construit à partir d'un anticorps naturel, et en amenant un monomère d'utéroglobine à muter, et un polypeptide bispécifique est construit en l'utilisant. 低分子量である二重特異性ポリペプチドを提供する。　天然抗体を基に作成される二重特性抗体におけるＦｃ部分を低分子のウテログロビンに変更し、ウテログロビンモノマーに変異を施し、ヘテロ二量体ウテログロビンを用意し、それを利用して二重特異性ポリペプチドを作成する。