COMPOUNDS

• Main Authors: QUEVEDO, Camilo, FALLON, Philip Spencer, PHILIPS, Simon, CRUZ, Abimael, FREEM, Joshua Robert, TRAORE, Tenin, RABBITTS, Terrence, WILLIAMS, Sophie Caroline, DUNN, Jonathan Neil, LEE, Lydia Yuen-Wah
• Format: Patent
• Language: English; French
• Published: 01.08.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to compounds of Formula I as defined herein, and salts and solvates thereof. (I) The present invention also relates to pharmaceutical compositions comprising compounds of Formula(I), and to compounds of Formula(I) for use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which inhibition of a RAS-effector protein-protein interaction is implicated. La présente invention concerne des composés de formule I tels que définis dans la description, et des sels et des solvates de ceux-ci. La présente invention concerne également des compositions pharmaceutiques comprenant des composés de formule (I), et des composés de formule (I) destinés à être utilisés dans le traitement de troubles prolifératifs, tels que le cancer, ainsi que d'autres maladies ou états dans lesquels l'inhibition d'une interaction protéine-protéine effectrice RAS est impliquée.