CLONAL HEMATOPOIESIS AND CYTOKINE TARGETS

As demonstrated herein, a preferential and progressive expansion of a subset of hematopoietic cells bearing somatic mutations in one or more HSC cardiometabolic driver genes leads to pro-inflammatory signaling at multiple levels. Accordingly, provided herein are compositions, methods, and assays for...

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Bibliographic Details
Main Authors SANO, Soichi, WALSH, Kenneth, OSHIMA, Kosei
Format Patent
LanguageEnglish
French
Published 25.07.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PHYSICS
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:As demonstrated herein, a preferential and progressive expansion of a subset of hematopoietic cells bearing somatic mutations in one or more HSC cardiometabolic driver genes leads to pro-inflammatory signaling at multiple levels. Accordingly, provided herein are compositions, methods, and assays for modulating a HSC cardiometabolic driver gene mutation-mediated proinflammatory activity. Comme démontré dans la présente description, une expansion préférentielle et progressive d'un sous-ensemble de cellules hématopoïétiques portant des mutations somatiques dans un ou plusieurs gènes moteurs cardiométaboliques des CSH conduit à une signalisation pro-inflammatoire à de multiples niveaux. Par conséquent, la présente invention concerne des compositions, des méthodes et des dosages permettant de moduler une activité pro-inflammatoire médiée par des mutations de gènes moteurs cardiométaboliques des CSH.
Bibliography:Application Number: WO2019US13750