METHOD OF USE OF YKL-40 IN SCOLIOSIS

Disclosed herein are novel molecular markers in the CHI3L1 gene associated with idiopathic scoliosis (IS). Accordingly,the present disclosure concerns novel methods of identifying subjects at risk of developing IS or suffering from IS and of genotyping and classifying IS subjects into genetic and fu...

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Bibliographic Details
Main Authors NADA, Dina Tarek, SAMUELS, Mark E, MOREAU, Alain
Format Patent
LanguageEnglish
French
Published 25.07.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
TESTING
VINEGAR
WINE
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Summary:Disclosed herein are novel molecular markers in the CHI3L1 gene associated with idiopathic scoliosis (IS). Accordingly,the present disclosure concerns novel methods of identifying subjects at risk of developing IS or suffering from IS and of genotyping and classifying IS subjects into genetic and functional groups. Also provided are compositions, DNA chips and kits for applying the methods. Novel methods, uses and compositions for the prevention or treatment of IS by increasing the levels of YKL-40 polypeptide are also disclosed. L'invention concerne de nouveaux marqueurs moléculaires dans le gène CHI3L1 associés à la scoliose idiopathique (SI). La présente invention concerne par conséquent de nouvelles méthodes permettant d'identifier des sujets présentant un risque de développer une SI ou atteint d'une SI, et de génotyper les sujets SI et de les classer dans des groupes génétiques et fonctionnels. L'invention concerne également des compositions, des puces à ADN et des kits permettant d'exécuter lesdites méthodes. L'invention concerne également de nouvelles méthodes, utilisations et compositions pour la prévention ou le traitement de l'IS par l'augmentation des niveaux du polypeptide YKL-40.
Bibliography:Application Number: WO2019CA50054