ARYLPYRAZOLYLPIPERAZINE OR ARYLPYRAZOLYLDIAZEPANE DERIVATIVE ACTING AS 5-HT7 RECEPTOR REGULATOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME FOR TREATMENT OR PREVENTION OF CENTRAL NERVOUS SYSTEM DISORDER

• Main Authors: LEE, Jung Eun, KIM, Hyung Guk, LIM, Sang Min, LEE, Hyunjoo Jenny, SEONG, Jihye, KIM, Youngjae, KWAG, Rina, YEOM, Miyoung, CHOO, Hyunah
• Format: Patent
• Language: English; French; Korean
• Published: 06.06.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to an arylpyrazolylpiperazine or arylpyrazolyldiazepane derivative represented by Structural Formula 1 and a pharmaceutically acceptable salt thereof. An arylpyrazolylpiperazine or arylpyrazolyldiazepane derivative and a pharmaceutically acceptable salt thereof according to the present invention exhibit excellent affinity for serotonin 5-HT7 receptor and can exert a therapeutic effect on a central nervous system disorder. La présente invention concerne un dérivé d'arylpyrazolylpipérazine ou d'arylpyrazolyldiazépane représenté par la formule de structure (1) et un sel pharmaceutiquement acceptable de celui-ci. Le dérivé d'arylpyrazolylpipérazine ou d'arylpyrazolyldiazépane et un sel pharmaceutiquement acceptable de celui-ci selon la présente invention présentent une excellente affinité pour le récepteur sérotoninergique 5-HT7 et peuvent exercer un effet thérapeutique sur un trouble du système nerveux central. 본 발명은 구조식 1로 표시되는 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 약제학적으로 허용 가능한 이의 염에 관한 것이다. 이에 따라, 본 발명의 아릴피라졸릴피페라진 또는 아릴피라졸릴다이아제페인의 유도체 및 약제학적으로 허용 가능한 이의 염은 5-HT7 세로토닌 수용체에 대하여 우수한 결합친화력을 나타내며, 중추신경계 질환 치료에 효과를 나타낼 수 있다.