NOVEL TNF FAMILY LIGAND TRIMER-CONTAINING ANTIGEN BINDING MOLECULES

The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising two different fusion polypeptides that comprise a spacer domain, an antigen binding domain and three ectodomains of a TNF ligand member or fragments thereof, wherein two of said ectodomains are se...

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Bibliographic Details
Main Authors HESSE, Friederike, XU, Wei, GEORGES, Guy, IMHOF-JUNG, Sabine, DUERR, Harald, FERRARA KOLLER, Claudia, CLAUS, Christina
Format Patent
LanguageEnglish
French
Published 09.05.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising two different fusion polypeptides that comprise a spacer domain, an antigen binding domain and three ectodomains of a TNF ligand member or fragments thereof, wherein two of said ectodomains are separated from each other by a spacer domain comprising at least 25 amino acids and wherein the two fusion polypeptides are covalently associated to each other in the spacer domain. L'invention concerne de nouvelles molécules de liaison à l'antigène contenant un trimère de ligands de la famille du TNF, comprenant deux polypeptides de fusion différents qui comprennent un domaine espaceur, un domaine de liaison à l'antigène et trois ectodomaines d'un membre des ligands du TNF ou de fragments correspondants, deux desdits ectodomaines étant séparés l'un de l'autre par un domaine espaceur comprenant au moins 25 acides aminés, et les deux polypeptides de fusion étant associés l'un à l'autre de manière covalente dans le domaine espaceur.
Bibliography:Application Number: WO2018EP79784