BISPECIFIC ANTIBODIES BINDING ALK-1 AND BMPR-2

Bispecific antibodies binding ALK-1 and BMPR-2 The present invention relates to bispecific antibodies binding human ALK-1 and human BMPR-2. Also provided are BsABs which are agonists of ALK-1/BMPR-2 signaling, and BsABs which do not trigger osteogenic signaling. Furthermore, the invention relates to...

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Bibliographic Details
Main Authors WEBER, Ernst, GLÜCK, Julian, SOHLER, Florian, MEDING, Jörg
Format Patent
LanguageEnglish
French
Published 13.06.2019
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Summary:Bispecific antibodies binding ALK-1 and BMPR-2 The present invention relates to bispecific antibodies binding human ALK-1 and human BMPR-2. Also provided are BsABs which are agonists of ALK-1/BMPR-2 signaling, and BsABs which do not trigger osteogenic signaling. Furthermore, the invention relates to pharmaceutical uses of the BsABs, in particular for the treatment of pulmonary hypertension. Also provided are methods to screen for BsABs for use in the therapy, e.g.of pulmonary hypertension. Des anticorps bispécifiques se liant à ALK-1 et BMPR-2 de la présente invention concernent des anticorps bispécifiques se liant à l'ALK-1 humain et au BMPR-2 humain. L'invention concerne également des BsABs qui sont des agonistes de la signalisation ALK-1/BMPR-2, et des BsABs qui ne déclenchent pas de signalisation ostéogénique. En outre, l'invention concerne des utilisations pharmaceutiques des BsABs, en particulier pour le traitement de l'hypertension pulmonaire. L'invention concerne enfin des procédés de criblage des BsABs destinés à être utilisés dans la thérapie, par exemple, de l'hypertension pulmonaire.
Bibliography:Application Number: WO2018EP79333