ANTI-MERTK ANTIBODIES AND METHODS OF USE THEREOF

Provided herein are compositions, methods and uses involving antibodies that specifically bind to MerTK, a receptor tyrosine kinase, and modulate the expression and/or activity of MerTK. Also provided are uses and methods for managing, treating, or preventing disorders, such as cancer. L'invent...

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Main Authors SURADE, Sachin, MURPHY, Michael, DYSON, Michael, ALVARADO, Diego, DUVA, Valerie, TROMBETTA, Eduardo, GEDRICH, Richard, KELER, Tibor, O'NEILL, Tom, MCCAFFERTY, John, VITALE, Laura
Format Patent
LanguageEnglish
French
Published 02.05.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compositions, methods and uses involving antibodies that specifically bind to MerTK, a receptor tyrosine kinase, and modulate the expression and/or activity of MerTK. Also provided are uses and methods for managing, treating, or preventing disorders, such as cancer. L'invention concerne des compositions, des procédés et des utilisations impliquant des anticorps qui se lient de manière spécifique à MerTK, un récepteur de tyrosine kinase, et qui modulent l'expression et/ou l'activité de MerTK. L'invention concerne également des utilisations et des procédés permettant de gérer, de traiter ou de prévenir des troubles, tels que le cancer.
Bibliography:Application Number: WO2018US57571