STABLE VACCINE COMPOSITIONS COMPRISING INTER ALIA LIVE ATTENUATED RECOMBINANT FLAVIVIRUS AND PROCESS FOR PREPARATION THEREOF
Stable lyophilized immunogenic compositions comprising inter alia live attenuated recombinant flaviviruses, more preferably live attenuated recombinant dengue viruses, at least one carbohydrate, at least one amino acid and is particularly amenable to rapid freeze-drying treatments wherein, the compo...
Saved in:
Main Authors | , , , , , , |
---|---|
Format | Patent |
Language | English French |
Published |
25.04.2019
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Stable lyophilized immunogenic compositions comprising inter alia live attenuated recombinant flaviviruses, more preferably live attenuated recombinant dengue viruses, at least one carbohydrate, at least one amino acid and is particularly amenable to rapid freeze-drying treatments wherein, the composition preserves desired characteristics of a virus, including virus viability, immunogenicity and stability. The said immunogenic composition is devoid of preservatives, polymers and surfactants. The methods for manufacturing said stable lyophilized immunogenic compositions.
L'invention concerne des compositions immunogènes lyophilisées stables comprenant, entre autres, des flavivirus recombinants vivants atténués, de préférence des virus recombinants vivants atténués de la dengue, au moins un glucide, au moins un acide aminé, et est particulièrement apte à des traitements de lyophilisation rapide, la composition conservant les caractéristiques souhaitées d'un virus, y compris la viabilité, l'immunogénicité et la stabilité du virus. Ladite composition immunogène est exempte de conservateurs, de polymères et de tensioactifs. L'invention concerne également les procédés de préparation desdites compositions immunogènes lyophilisées stables. |
---|---|
Bibliography: | Application Number: WO2018IN50645 |