BIOCONJUGATION OF POLYPEPTIDES

Certain embodiments of the present invention relate to methods of forming and manipulating bioconjugates. Particularly, but not exclusively certain embodiments relate to methods of reversible carbon-carbon bond bioconjugation using aldol based chemical reactions at physiological conditions. Selon ce...

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Bibliographic Details
Main Authors SPEARS, Richard J, KEENAN, Tessa, BRABHAM, Robin, FASCIONE, Martin A, BUDHADEV, Darshita
Format Patent
LanguageEnglish
French
Published 04.04.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Certain embodiments of the present invention relate to methods of forming and manipulating bioconjugates. Particularly, but not exclusively certain embodiments relate to methods of reversible carbon-carbon bond bioconjugation using aldol based chemical reactions at physiological conditions. Selon certains modes de réalisation, la présente invention concerne des procédés de formation et de manipulation de bioconjugués. En particulier, mais sans caractère exclusive, certains modes de réalisation de la présente invention concernent des procédés de bioconjugaison de liaison carbone-carbone réversible utilisant des réactions chimiques à base d'aldol dans des conditions physiologiques.
Bibliography:Application Number: WO2017GB52896