MODIFIED 5'-UNTRANSLATED REGION (UTR) SEQUENCES FOR INCREASED PROTEIN PRODUCTION IN BACILLUS

The present disclosure is generally modified Bacillus strains and host cells thereof capable of producing increased amounts of industrially relevant proteins of interest. Other embodiments of the disclosure are related to isolated polynucleotides comprising modified Bacillus subtilis aprE 5'-un...

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Bibliographic Details
Main Authors DE LANGE, Dennis, FRISCH, Ryan L, MASSON, Helen Olivia
Format Patent
LanguageEnglish
French
Published 21.03.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The present disclosure is generally modified Bacillus strains and host cells thereof capable of producing increased amounts of industrially relevant proteins of interest. Other embodiments of the disclosure are related to isolated polynucleotides comprising modified Bacillus subtilis aprE 5'-untranslated region (5'-UTR) nucleic acid sequences, vectors thereof, DNA (expression) constructs thereof, modified Bacillus (daughter) cells thereof, and methods of making and using the same. La présente invention concerne, de manière générale, des souches de Bacillus modifiées et des cellules hôtes de celles-ci capables de produire des quantités accrues de protéines d'intérêt industriellement pertinentes. D'autres modes de réalisation de l'invention concernent des polynucléotides isolés comprenant des séquences d'acides nucléiques de région 5' non traduite (5'-UTR) de Bacillus subtilis aprE, des vecteurs de celles-ci, des constructions d'ADN (expression) de celles-ci, des cellules (filles) de Bacillus modifiées de celles-ci, et des procédés de fabrication et d'utilisation de celles-ci.
Bibliography:Application Number: WO2018US49470