PYRUVATE KINASE ACTIVATORS FOR USE IN TREATING BLOOD DISORDERS

Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein. L'invention concerne des composés qui activent la pyruvate kinase, de...

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Bibliographic Details
Main Authors CUI, Dawei, LIU, Tao, JI, Jingjing, CIANCHETTA, Giovanni, SUI, Zhihua, PADYANA, Anil, CAI, Zhenwei
Format Patent
LanguageEnglish
French
Published 28.03.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Described herein are compounds that activate pyruvate kinase, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I) wherein R1, R2, Ra, Rb, Rj, Rk, and Q are as defined herein. L'invention concerne des composés qui activent la pyruvate kinase, des compositions pharmaceutiques et des procédés d'utilisation de ceux-ci. Ces composés sont représentés par la formule (I) dans laquelle R1, R2, Ra, Rb, Rj, Rk, et Q sont tels que définis dans la description.
Bibliography:Application Number: WO2018US00128