FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITOR AND USE THEREOF

Provided are a fibroblast growth factor receptor (FGFR) irreversible inhibitor as represented by formula I, a pharmaceutically acceptable salt, a stereoisomer thereof, and pharmaceutical preparations, pharmaceutical compositions and uses of these compounds. Said compounds have an efficient and highl...

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Bibliographic Details
Main Author WU, Frank
Format Patent
LanguageChinese
English
French
Published 14.02.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are a fibroblast growth factor receptor (FGFR) irreversible inhibitor as represented by formula I, a pharmaceutically acceptable salt, a stereoisomer thereof, and pharmaceutical preparations, pharmaceutical compositions and uses of these compounds. Said compounds have an efficient and highly selective inhibitory effect on FGFR, and can be used for the treatment of related diseases mediated by FGF/FGFR abnormality, especially for the treatment of cancer diseases. L'invention concerne un inhibiteur irréversible du récepteur du facteur de croissance des fibroblastes (FGFR) tel que représenté par la formule I, un sel pharmaceutiquement acceptable, un stéréoisomère de celui-ci, et des préparations pharmaceutiques, des compositions pharmaceutiques et des utilisations de ces composés. Lesdits composés ont un effet inhibiteur efficace et hautement sélectif sur FGFR, et peuvent être utilisés pour le traitement de maladies associées induites par une anomalie FGF/FGFR, en particulier pour le traitement de malad
Bibliography:Application Number: WO2018CN99242