IMMUNOGENIC COMPOSITIONS COMPRISING CEA MUC1 AND TERT

• Main Authors: BINDER, Joseph John, CHO, Helen Kim, GURU, Siradanahalli, MARTINIC, Marianne Marcela Andrea, FALCONER, Derek John, COCKLE, Paul Jason
• Format: Patent
• Language: English; French
• Published: 17.01.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present disclosure provides: (a) isolated immunogenic CEA polypeptides; (b) isolated nucleic acid molecules encoding (i) an immunogenic CEA polypeptide, (ii) an immunogenic CEA polypeptide and an immunogenic MUC1 polypeptide, (iii) an immunogenic CEA polypeptide and an immunogenic TERT polypeptide, or (iv) an immunogenic CEA polypeptide, an immunogenic MUC1 polypeptide, and an immunogenic TERT polypeptide; (c) compositions comprising an isolated nucleic acid molecule; and (d) methods relating to uses of the immunogenic CEA polypeptides, nucleic acid molecules, and compositions. La présente invention concerne : (a) des polypeptides CEA immunogènes isolés; (b) des molécules d'acide nucléique isolées codant pour (i) un polypeptide CEA immunogène, (ii) un polypeptide CEA immunogène et un polypeptide MUC1 immunogène, (iii) un polypeptide CEA immunogène et un polypeptide TERT immunogène, ou (iv) un polypeptide CEA immunogène, un polypeptide MUC1 immunogène et un polypeptide TERT immunogène; (c) des compositions comprenant une molécule d'acide nucléique isolée; et (d) des procédés se rapportant à des utilisations des polypeptides CEA immunogènes, des molécules d'acide nucléique et des compositions.