COMPOSITION FOR PREVENTING OR TREATING METABOLIC DISEASES

• Main Authors: LEE, Do Heon, YOON, You Sik, CHAE, Seyeon, LEE, Sang yeon, JANG, Jae Woong
• Format: Patent
• Language: English; French; Korean
• Published: 20.12.2018
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a composition for preventing or treating metabolic diseases and, more particularly, to a pharmaceutical composition and a food composition for preventing, alleviating, or treating metabolic diseases, comprising an extract of Gentianae Macrophyllae Radix as an active ingredient. The method of the present invention promotes AMPK activity; inhibits fat accumulation, fat granulation, lipogenesis transcription factor SREBP-1c activity, and lipogenic enzyme expression; and reduces body weight, fat tissue and liver tissue weight, blood glucose, triglycerides, and cholesterol content, and thus may be effectively used for preventing or treating metabolic diseases such as obesity, diabetes, hypertriglyceridemia, hypercholesterolemia, and the like. La présente invention concerne une composition pour prévenir ou traiter les maladies métaboliques et, plus particulièrement, une composition pharmaceutique et une composition alimentaire pour prévenir, atténuer ou traiter les maladies métaboliques, comprenant un extrait de Gentianae Macrophyllae Radix à titre de principe actif. La méthode selon la présente invention favorise l'activité AMPK; inhibe l'accumulation de graisse, la granulation de la graisse, l'activité du facteur de transcription de lipogenèse SREBP-1c, et l'expression des enzymes lipogéniques; et réduit le poids corporel, le tissu adipeux et le poids de tissu hépatique, la glycémie, les triglycérides et la teneur en cholestérol, et peut ainsi être utilisée efficacement pour prévenir ou traiter les maladies métaboliques telles que l'obésité, le diabète, l'hypertriglycéridémie, l'hypercholestérolémie, et autres. 본 발명은 대사성 질환 예방 또는 치료용 조성물에 관한 것으로, 보다 상세하게는 진교 추출물 (Gentianae Macrophyl lae Radix)을 유효성분으로 포함하는 대사성 질환 예방, 개선 또는 치료용 약학적 조성물 및 식품 조성물에 관한 것이다. 본 발명의 방법은 AMPK 활성을 촉진시키고, 지방 축적, 지방 과립,지방합성전사인자 SREBP-1c 활성 및 지방합성효소 발현을 억제하고, 체중, 지방조직 및 간조직 중량, 혈당, 중성지방 및 콜레스테를 함량을 감소시켜 비만, 당뇨,고중성지방혈증, 고콜레스테를 혈증 등의 대사성 질환을 예방하거나 치료하는 데에 유용하게 이용될 수 있다.