PREPARATION METHOD FOR SUBSTITUTED PHENYLACETIC ACID DERIVATIVE

• Main Authors: LIU, Shengmin, ZHENG, Juncheng, WANG, Changfa, LIU, Aqing, HU, Kai, ZHEN, Hui, GAO, Zhaobo, GUO, Bibao, SONG, Liang, MEI, Yijiang, LI, Jieping
• Format: Patent
• Language: Chinese; English; French
• Published: 20.12.2018
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The present invention belongs to the field of pharmaceutical synthesis, and relates to a preparation method for a substituted phenylacetic acid derivative, in particular to a method for preparing 2-[4-(2-oxopentylmethyl)phenylpropionic acid]. Said preparation method comprises a Friedel-Crafts reaction, and a cyclization reaction and a coupling reaction of which the sequence can be exchangeable, and a reduction reaction. The preparation method is neither taught in the prior art, nor can any technical motivation be obtained from the prior art. The preparation method is suitable for the production in commercial scale, and provides another technical solution for the industrial production of loxoprofen sodium. La présente invention se rapporte au domaine de la synthèse pharmaceutique, et concerne un procédé de préparation d'un dérivé d'acide phénylacétique substitué, en particulier un procédé de préparation de l'acide 2-[4-(2-oxopentylméthyl)phénylpropionique]. Ledit procédé de préparation comprend une réaction de