6-PYRIMIDIN-ISOINDOLE DERIVATIVE AS ERK1/2 INHIBITOR

This invention relates to the compound (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1 -oxo-2,3-dihydro-1 H-isoindol-2-yl)-N-[(1 S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide, and in particular to novel physical forms of the compound, a process for preparing the compound and s...

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Main Authors WILSHER, Nicola Elizabeth, LINDLEY, Colin Thomas, READER, Michael, BAGULEY, Paul Anthony, MELLING, Robert Craig, SCARATI, Mirka, SAUNDERS, Mark Henry, ADAMCZYK, Bozena Ewa
Format Patent
LanguageEnglish
French
Published 25.10.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to the compound (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1 -oxo-2,3-dihydro-1 H-isoindol-2-yl)-N-[(1 S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide, and in particular to novel physical forms of the compound, a process for preparing the compound and synthetic intermediates for use in the process, and novel formulations containing the compound, as well as therapeutic uses of the compound. La présente invention concerne le composé (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1 -oxo-2,3-dihydro-1 H-isoindol-2-yl)-N-[(1 S)-1-(3-fluoro-5-méthoxyphényl)-2-hydroxyéthyl]propanamide, et en particulier de nouvelles formes physiques du composé, un procédé de préparation dudit composé et des intermédiaires synthétiques destinés à être utilisés dans le procédé, ainsi que de nouvelles formulations contenant le composé, et des utilisations thérapeutiques de ce dernier.
Bibliography:Application Number: WO2018IB52745