UNYLINKER RAPID CLEAVAGE

The present invention relates to the field of oligonucleotide synthesis using a solid support and in particular to the finding the when using a 3' oxy-LNA nucleoside attached to the solid support of the UnyLinker types, cleavage and deprotection occurs very rapidly. La présente invention concer...

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Bibliographic Details
Main Authors MOGENSEN, Marianne, HANSEN, Dennis Jul, MELDGAARD, Michael
Format Patent
LanguageEnglish
French
Published 04.10.2018
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Summary:The present invention relates to the field of oligonucleotide synthesis using a solid support and in particular to the finding the when using a 3' oxy-LNA nucleoside attached to the solid support of the UnyLinker types, cleavage and deprotection occurs very rapidly. La présente invention concerne le domaine de la synthèse d'oligonucléotides à l'aide d'un support solide et, concerne particulièrement, la découverte que le clivage et la déprotection se produisent très rapidement, lors de l'utilisation d'un nucléoside 3'oxy-LNA fixé au support solide des lieurs de type UnyLinker.
Bibliography:Application Number: WO2018EP57296