QUINOLINE-5,8-DIONE DERIVATIVE AS TGASE 2 INHIBITOR, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

• Main Authors: PARK, Gayoung, HWANG, Hee-Jong, LEE, Eunhye, KANG, Jihee, WOO, Seo Yeon, IM, Chun Young, KIM, Hyoji, KIM, Soong-Hyun, KIM, Soo Youl, SONG, Minsoo, KO, Eun Bi
• Format: Patent
• Language: English; French; Korean
• Published: 20.09.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a quinoline-5,8-dione derivative compound represented by chemical formula I, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The compound represented by chemical formula I, of the present invention, has a TGase 2 inhibitory effect, and a pharmaceutical composition containing the same can be useful for preventing or treating disorders or diseases which are mediated by TGase 2 or which react to TGase 2 inhibition. La présente invention concerne un composé dérivé de quinoléine-5,8-dione représenté par la formule chimique (I), son stéréoisomère, ou son sel pharmaceutiquement acceptable. Le composé représenté par la formule chimique (I), de la présente invention, présente un effet d'inhibition de la TGase (2), et une composition pharmaceutique le contenant peut être utile pour prévenir ou traiter les troubles ou les maladies qui sont médiés-es par la TGase (2) ou qui réagissent à l'inhibition de la TGase (2). 본 발명은 화학식 I로 표시되는 퀴놀린-5,8-디온 유도체 화합물, 이의 입체이성질체 또는 약제학적으로 허용되는 이의 염에 대한 것이다. 본 발명의 화학식 I로 표시되는 화합물은, TGase 2 저해 효과를 갖고, 이를 포함하는 약제학적 조성물은 TGase 2에 의해 매개되거나 TGase 2의 억제에 대해 반응하는 장애 또는 질환의 예방 또는 치료에 유용하게 사용될 수 있다.