COMPOSITIONS WITH IMPROVED INTRAVITREAL HALF-LIFE AND USES THEREOF

• Main Authors: ERICKSON, Carl, QUICK, Ryan, RUSCONI, Christopher P, MCLURE, Kevin G, HUTABARAT, Renta
• Format: Patent
• Language: English; French
• Published: 16.08.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided herein are compositions and methods for the treatment of retinal diseases. The compositions and methods include a therapeutic agent conjugated to a vitreous component binding moiety. The vitreous component binding moiety may be an aptamer or a small molecule that binds to a structural component of the vitreous humor (e.g., hyaluronic acid, collagen or vitronectin). L'invention concerne des compositions et des méthodes de traitement des maladies rétiniennes. Les compositions et méthodes selon l'invention comprennent un agent thérapeutique conjugué à une fraction de liaison à un composant vitré. La fraction de liaison à un composant vitré la vitronectine). peut être un aptamère ou une petite molécule se liant à un composant structurel du corps vitré (par exemple, de l'acide hyaluronique, du collagène ou de la vitronectine).