CHIMERIC ANTIGEN RECEPTOR AND NATURAL KILLER CELLS EXPRESSING SAME

• Main Authors: JUNG, Mi Young, LEE, Eun Sol, HER, Jung Hyun, WON, Sung Yong, KIM, Han Sol, KIM, Hyun Ah, LIM, Ho Yong, HWANG, Yu Kyeong, CHO, Sung Yoo, GWON, Su Hyun
• Format: Patent
• Language: English; French; Korean
• Published: 17.01.2019
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention relates to a chimeric antigen receptor and natural killer cells expressing the same and, more particularly, to a chimeric antigen receptor (CAR) comprising an intracellular signaling domain including all or a part of an OX40 ligand (CD252), thereby having an excellent anticancer activity enhancing effect on immune cells, and immune cells expressing the same. La présente invention concerne un récepteur antigénique chimérique et des cellules tueuses naturelles exprimant celui-ci et, plus particulièrement, un récepteur antigénique chimérique (CAR) qui comprend un domaine de signalisation intracellulaire comprenant tout ou partie d'un ligand OX40 (CD252), ayant ainsi un excellent effet d'amélioration de l'activité anticancéreuse sur des cellules immunitaires, et des cellules immunitaires exprimant celui-ci. 본 발명은 키메라 항원 수용체 및 이를 발현하는 자연 살해 세포에 관한 것으로서, OX40 리간드 (CD252)의 전체 또는 일부를 포함하는 세포내 신호전달 도메인 (intracellular signaling domain)을 포함함으로써 면역세포의 항암 활성 증대 효과가 우수한 키메라 항원 수용체 (chimeric antigen receptor, CAR) 및 이를 발현하는 면역세포에 관한 것이다.