COMPOUND BEARING BETA-GALACTOSIDE-INTRODUCED SELF-IMMOLATIVE LINKER

• Main Authors: JUNG, Doo Hwan, KIM, Sun Young, LEE, Hyang Sook, LIM, Ji Yeon, LEE, Sang Kwang, SEO, Dong Hoon, CHO, Jong Un, WOO, Sung Ho, PARK, Su Ho, PARK, Tae Kyo, LEE, Jae Ho, SEO, Beom Seok
• Format: Patent
• Language: English; French; Korean
• Published: 23.08.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a compound bearing a self-immolative linker having β-galactoside introduced thereto. In a compound bearing a β-galactoside-introduced self-immolative linker according to the present invention, particularly, the self-immolative linker may form a glycosidic bond with a protein (e.g., an oligopeptide, a polypeptide, an antibody, etc.) or ligand which has specific affinity for a desired target or with an active agent (e.g., a drug, a toxin, a ligand, a detection probe, etc.) which has a specific function or activity so as to allow the selective release of the active agent within a target cell. La présente invention concerne un composé portant un lieur auto-immolable dans lequel du bêta-galactoside est introduit. Dans un composé portant un lieur auto-immolable à bêta-galactoside introduit selon la présente invention, en particulier, le lieur auto-immolable peut former une liaison glycosidique avec une protéine (par exemple, un oligopeptide, un polypeptide, un anticorps, etc.) ou un ligand qui a une affinité spécifique pour une cible souhaitée ou avec un agent actif (par exemple, un médicament, une toxine, un ligand, une sonde de détection, etc.) qui a une fonction ou une activité spécifique de façon à permettre la libération sélective de l'agent actif à l'intérieur d'une cellule cible. 본 발명은 β-갈락토사이드(β-galactoside)가 도입된 자가-희생 기(self-immolative linker)를 포함하는 화합물에 관한 것으로, 보다 상세하게는 본 발명의 β-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물은 목적하는 표적에 대한 결합 특이성을 갖는 단백질(예: 올리고펩티드, 폴리펩티드, 항체 등) 또는 리간드, 특이적 기능 또는 활성을 갖는 활성제(예: 약물, 독소, 리간드, 검출용 탐침 등) 및 타겟 세포내에서 선택적으로 활성제가 방출될 수 있도록 글라이코사이드 결합(glycosidic bond)을 이루고 있는 자가-희생 기를 포함할 수 있다.