4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS

The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines as type II topoisomerase inhibitors and use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4- amino-2-pyrido bicyclic pyrimidines. La présente invention con...

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Bibliographic Details
Main Authors SISSI, Claudia, ARENCIBIA JIMENEZ, Jose Manuel, MINARINI, Anna, DE VIVO, Marco, ORTEGA MARTINEZ, Jose Antonio
Format Patent
LanguageEnglish
French
Published 28.06.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines as type II topoisomerase inhibitors and use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4- amino-2-pyrido bicyclic pyrimidines. La présente invention concerne des pyrimidines 4-amino-2-pyrido-bicycliques en tant qu'inhibiteurs de la topoisomérase de type II et leur utilisation en tant que médicaments notamment dans le traitement du cancer. L'invention concerne également un procédé de fabrication de pyrimidines bicycliques de 4- amino-2-pyrido.
Bibliography:Application Number: WO2017EP83087