MULTI-KINASE INHIBITOR COMPOUND, AND CRYSTAL FORM AND USE THEREOF

• Main Author: WU, Frank
• Format: Patent
• Language: Chinese; English; French
• Published: 21.06.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a compound as represented by formula (I) or a pharmaceutically acceptable salt and stereoisomer thereof, wherein R1, R2, X, Y, P, W, and Ar are as defined in the description. The compound of formula (I) of the present invention can be used in the preparation of a drug for treating cancers mediated by multi-kinase abnormalities. Also provided is a crystal form I of a compound 4-(5-(2-chlorophenyl)-3-methyl-2,10-dihydropyrazole[4,3-b]pyrido[4,3-e] [1,4]diazepin-8-yl)morpholine, wherein in an X-ray powder diffraction pattern of crystal form I, there are characteristic peaks at 7.4 ± 0.2°, 17.9 ± 0.2°, 18.9 ± 0.2°, 19.4 ± 0.2°, 21.5 ± 0.2°, and 23.7 ± 0.2°. La présente invention concerne un composé tel que représenté par la formule (I) ou un sel pharmaceutiquement acceptable et un stéréoisomère de celui-ci, dans la formule R1, R2, X, Y, P, W et Ar sont tels que définis dans la description. Le composé de formule (I) de la présente invention peut être utilisé dans la préparation d'u