MET ANTIBODY DRUG CONJUGATES

Provided are antibody-drug conjugates (ADCs) that bind to, and kill MET expressing tumor cells, and that are effective in treating MET expressing cancers. Also provided are novel compounds and methods of conjugating MET antibodies to generate such ADCs. L'invention concerne des conjugués antico...

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Bibliographic Details
Main Authors LI, Renhua, FENG, Yiqing, HIPSKIND, Philip Arthur, WILSON, Takako, LIU, Ling, WROBLESKI, Aaron David
Format Patent
LanguageEnglish
French
Published 31.05.2018
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are antibody-drug conjugates (ADCs) that bind to, and kill MET expressing tumor cells, and that are effective in treating MET expressing cancers. Also provided are novel compounds and methods of conjugating MET antibodies to generate such ADCs. L'invention concerne des conjugués anticorps-médicament (CAM) qui se lient à, et tuent les cellules tumorales exprimant MET, et qui sont efficaces dans le traitement de cancers exprimant MET. L'invention concerne également de nouveaux composés et des procédés de conjugaison d'anticorps anti-MET pour générer de tels CAM.
Bibliography:Application Number: WO2017US62247