PROCESS FOR PREPARATION OF ERIBULIN AND INTERMEDIATES THEREOF

The present application relate to process for preparation of tetrahydrofuran compound of formula II, 4-Methylene tetrahydrofuran compound of formula V and tetrahydropyran compound of formula IX which are useful as intermediates for the preparation of halichondrin B analogues such as Eribulin or its...

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Main Authors SARVESH, Kumar, WARREN, Sarah Ann, PENUMANDLA, Raja gopal, ORUGANTI, Srinivas, DAHANUKAR, Vilas Hareshwar, MANDAL, Amit Kumar, EDA, Vishnu Vardhana Vema Reddy, FOX, Martin Edward, LLOYD, Michael Charles, RAO, Pallavi, PALVAI, Prapulla Kumar, MEEK, Graham Andrew, DAVIDSON, Robert Wen Ming, BASU, Debjit
Format Patent
LanguageEnglish
French
Published 31.05.2018
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Summary:The present application relate to process for preparation of tetrahydrofuran compound of formula II, 4-Methylene tetrahydrofuran compound of formula V and tetrahydropyran compound of formula IX which are useful as intermediates for the preparation of halichondrin B analogues such as Eribulin or its pharmaceutically acceptable salts. La présente invention concerne un procédé de préparation d'un composé de tétrahydrofurane de formule II, un composé 4-méthylène tétrahydrofurane de formule V et un composé tétrahydropyrane de formule IX qui sont utiles en tant qu'intermédiaires pour la préparation d'analogues de halichondrine B tels que l'éribuline ou ses sels pharmaceutiquement acceptables.
Bibliography:Application Number: WO2017IB57352