Dihydroxyphenyl Sulfonylisoindoline Derivatives

Provided are compounds that are inhibitors of pyruvate dehydrogenase kinase (PDK), and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an...

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Bibliographic Details
Main Authors LOU, Mingliang, WU, Qingcui, WU, Enlong, QI, Xiangbing, CHEN, Peihao
Format Patent
LanguageEnglish
French
Published 31.05.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are compounds that are inhibitors of pyruvate dehydrogenase kinase (PDK), and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition. L'invention concerne des composés qui sont des inhibiteurs de la pyruvate déshydrogénase kinase (PDK), et des sels, des hydrures et des stéréoisomères pharmaceutiquement acceptables de ceux-ci. Les composés sont utilisés dans des compositions pharmaceutiques et des procédés de fabrication et d'utilisation, notamment le traitement d'une personne en ayant besoin avec une quantité efficace du composé ou de la composition.
Bibliography:Application Number: WO2017CN111273