PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION AND TREATMENT COMPRISING TUBULOSINE

• Main Authors: YE, Sang-Kyu, KIM, Byung-Hak, LEE, Chung Gi
• Format: Patent
• Language: English; French; Korean
• Published: 24.05.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a pharmaceutical composition for cancer treatment comprising tubulosine as an active ingredient. In the composition of the present invention, tubulosine inhibits the catalytic activity of a JAK in leukemia and lymphoma cell lines, thereby entirely and strongly inhibits structurally activated cytokine-induced JAK3 signaling, and thus can be usefully employed as a preparation for inhibiting the survival and proliferation of active JAK-mediated cancer cells. L'invention concerne une composition pharmaceutique pour traiter le cancer comprenant de la tubulosine comme principe actif. Dans la composition de la présente invention, la tubulosine inhibe l'activité catalytique d'une JAK dans des lignées cellulaires de leucémie et de lymphome, inhibant ainsi entièrement et fortement la signalisation JAK3 induite par cytokine activée structurellement, et peut de ce fait être utilisée utilement comme préparation pour inhiber la survie et la prolifération de cellules cancéreuses médiées par l'activation de JAK. 본 발명은 튜불로신(tubulosine)을 유효성분으로 포함하는 암 치료용 약제학적 조성물에 관한 것이다. 본 발명의 조성물에서 튜불로신은 백혈병과 림프종 세포주에서 JAK 촉매 활성을 억제함으로써, 구조적으로 활성화된 사이토카인-유도성 JAK3 신호전달을 모두 강력하게 억제하므로, 활성 JAK-매개 암 세포의 생존 및 증식을 억제하는 제제로서 유용하게 사용될 수 있다.