ANTI-INFLAMMATORY COMPOSITION USING BLACK RADISH EXTRACT

• Main Authors: LEE, Hak Sung, YOON, Seon A, KIM, Hyun Kyu, OH, Dong Kwan, KO, Chang Sik, HONG, Seung Hyun, YANG, Da Wun, LEE, Seung Muk, KIM, Gi Ok, LEE, Yong Bum, SONG, Sang Mok, KIM, Seong Eun, JIN, Hyue Ju
• Format: Patent
• Language: English; French; Korean
• Published: 03.05.2018
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

Disclosed is an anti-inflammatory composition using a black radish extract. The black radish extracts inhibited secretion or production of NO, inflammatory cytokines (TNF-α, IL-6, IL-1β), PGE2, COX-2 and iNOS in mouse macrophage cell lines (RAW 264.7 cells) stimulated with lipopolysaccharide (LPS) and reduced phosphorylation of STAT3. In addition, phosphorylation of JAK2, STAT3 was reduced in mouse macrophage cell lines (RAW 264.7 cells) stimulated with IL-6. Therefore, the black radish extract of the present invention can be effectively used as a composition for preventing and treating inflammatory diseases such as rheumatoid arthritis, dermatitis and the like by inhibiting IL-6, JAK2, STAT3 signaling mechanisms. L'invention concerne une composition anti-inflammatoire faisant appel à un extrait de radis noir. L'extrait de radis noir inhibe la sécrétion ou la production de NO, de cytokines inflammatoires (TNF-α, IL-6, IL-1β), de PGE2, de COX-2 et d'iNOS dans des lignées cellulaires de macrophages murins (cellules RAW 264.7) stimulées par le lipopolysaccharide (LPS) et diminue la phosphorylation de STAT3. De plus, la phosphorylation de JAK2, STAT3 est diminuée dans des lignées cellulaires de macrophages murins (cellules RAW 264.7) stimulées par l'IL-6. Par conséquent, l'extrait de radis noir de la présente invention peut être utilisé efficacement comme composition permettant de prévenir et de traiter des maladies inflammatoires telles que la polyarthrite rhumatoïde, la dermatite, et similaires, en inhibant des mécanismes de signalisation de l'IL-6, JAK2 et STAT3. 본 발명은 흑무 추출물을 이용한 항염증용 조성물을 개시한다. 상기 흑무 추출물는 LPS(lipopolysacharide)로 자극된 마우스 대식세포주(RAW 264.7 cells)에서 NO, 염증성 사이토카인(TNF-α, IL-6, IL-1β), PGE2, COX-2 및 iNOS의 분비 또는 생성을 억제하였으며 STAT3의 인산화를 감소시켰다. 또한 IL-6 로 자극된 마우스 대식세포주(RAW 264.7 cells)에서 JAK2, STAT3의 인산화를 감소시켰다. 따라서 본 발명의 흑무 추출물은 IL-6, JAK2, STAT3 신호전달기작을 억제하여 류마티스 관절염, 피부염 등을 비롯한 염증성 질환의 예방 및 치료 조성물로 유용하게 이용될 수 있다.