METHOD FOR PRODUCING PELLETS FOR CONTROLLED DELIVERY OF AN ACTIVE

A process for preparing granules for delayed release of an active comprising: extruding a tube of biodegradable polymer; inserting within the tube a plurality of longitudinally spaced portions of a core matrix comprising the active; and sealing the tube between the longitudinally spaced portions to...

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Bibliographic Details
Main Authors PEETERS, Gary, EBDON, Nicholas, ADHIKARI, Raju, O'SHEA, Michael, Shane
Format Patent
LanguageEnglish
French
Published 05.04.2018
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Summary:A process for preparing granules for delayed release of an active comprising: extruding a tube of biodegradable polymer; inserting within the tube a plurality of longitudinally spaced portions of a core matrix comprising the active; and sealing the tube between the longitudinally spaced portions to form discrete granules comprising portions of core matrix. La présente invention concerne un procédé de préparation de granulés destinés à la libération retardée d'un principe actif, lequel procédé consiste : à extruder un tube de polymère biodégradable ; à insérer à l'intérieur du tube une pluralité de parties espacées longitudinalement d'une matrice centrale comprenant le principe actif; et à sceller le tube entre les parties espacées longitudinalement afin de former des granulés discrets comprenant des parties de matrice centrale.
Bibliography:Application Number: WO2017AU51067