UNSTRUCTURED NON-REPETITIVE POLYPEPTIDES HAVING LCST BEHAVIOR

Described herein are unstructured polypeptides lacking any discernible repeat motif. Also described herein are fusion proteins including at least one of the unstructured polypeptides and at least one binding polypeptide. Further described are methods for treating a disease in a subject in need there...

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Bibliographic Details
Main Authors CHILKOTI, Ashutosh, TANG, Nicholas, KELLY, Garrett
Format Patent
LanguageEnglish
French
Published 29.03.2018
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Described herein are unstructured polypeptides lacking any discernible repeat motif. Also described herein are fusion proteins including at least one of the unstructured polypeptides and at least one binding polypeptide. Further described are methods for treating a disease in a subject in need thereof. The methods may include administering to the subject an effective amount of the fusion protein. L'invention concerne des polypeptides non structurés dépourvus de motif répétitif discernable. L'invention concerne également des protéines de fusion comprenant au moins l'un des polypeptides non structurés et au moins un polypeptide de liaison. L'invention concerne en outre des méthodes de traitement d'une maladie chez un sujet en ayant besoin. Les méthodes peuvent comprendre l'administration au sujet d'une quantité efficace de la protéine de fusion.
Bibliography:Application Number: WO2017US52887