ACID ADDITION SALT OF BENZIMIDAZOLE DERIVATIVE

• Main Authors: KIM, Eun Sun, CHOI, Kwang Do, YOO, Hyung Chul, LEE, Sung Ah, LEE, Min Kyoung, KIM, Jae Sun
• Format: Patent
• Language: English; French; Korean
• Published: 29.03.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to pidolate and malate salts of a compound represented by chemical formula 1 and preparation methods therefor, wherein the compound has preventive and therapeutic uses for a disease mediated by acid pump antagonistic activity and is excellent in liquid-phase stability, solid-phase stability, solubility in water, precipitation stability, and hygroscopicity. La présente invention concerne des sels de pidolate et de malate d'un composé représenté par la formule chimique 1 et leurs procédés de préparation, le composé ayant des utilisations préventives et thérapeutiques pour une maladie médiée par l'activité antagoniste de la pompe à acide et présentant une excellente stabilité en phase liquide, en phase solide, dans l'eau, en précipitation et une hygroscopicité. 본 발명은 산 펌프 길항 활성에 의해 매개되는 질환의 예방 및 치료용도를 갖는 화합물로서 액상 안정성과 고체상 안정성, 수용해도, 석출 안정성, 흡습성이 모두 우수한 화학식 1로 표시되는 화합물의 피돌레이트 염 및 말레이트 염, 및 이들의 제조방법에 관한 것이다.