DEGLYCOSYLATED ANTIBODY SPECIFICALLY BINDING TO CLEC14A AND USES THEREOF

• Main Authors: LEE, Sukmook, KIM, Taek-Keun, JANG, Ji Hye, KIM, Mi Ra
• Format: Patent
• Language: English; French; Korean
• Published: 15.03.2018
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a deglycosylated antibody which specifically binds to C-type lectin domain family 14, member A (clec14a), and uses thereof. More specifically, the present invention relates to a deglycosylated antibody which comprises a light chain variable region including CDR1 of a particular sequence and specifically binds to clec14, and uses thereof, such as a pharmaceutical composition for the prevention or treatment of angiogenesis-related diseases comprising the antibody. La présente invention concerne un anticorps déglycosylé qui se lie spécifiquement à la famille 14 du domaine de la lectine de type C, élément A (clec14a) et ses utilisations. Plus spécifiquement, la présente invention concerne un anticorps déglycosylé qui comprend une région variable de chaîne légère comprenant une région CDR1 d'une séquence particulière et se lie spécifiquement à clec14, et leurs utilisations, telles qu'une composition pharmaceutique pour la prévention ou le traitement de maladies associées à l'angiogenèse comprenant l'anticorps. 본 발명은 C-타입 렉틴 도메인 패밀리 14, 멤버 A(clec14a)에 특이적으로 결합하는 탈당화 항체 및 그 용도에 관한 것이다. 더욱 상세하게, 본 발명은 특정 서열의 CDR1을 포함하는 경쇄 가변영역을 포함하고, clec14에 특이적으로 결합하는 탈당화 항체 및 이의 용도 예를 들어, 상기 항체를 포함하는 혈관신생 관련 질환 예방 또는 치료용 약학적 조성물에 관한 것이다.