EXTENDED RELEASE MICROSPHERE TO WHICH RELEASE INHIBITOR COMPRISING OIL, IN WHICH C18:1, C18:1(OH) OR C18:2 LONG-CHAIN FATTY ACID IS CONTAINED, IS APPLIED AND PREPARATION METHOD THEREFOR

• Main Authors: YOO, Ji-Seok, PARK, Young Joon, LIM, Duck Soo, KIM, Byoung Ki, KIM, Dae Hyeon
• Format: Patent
• Language: English; French; Korean
• Published: 01.03.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a long-term extended release microsphere containing a bioactive material, and a preparation method therefor, and provides: a long-term extended release microsphere, which comprises a bioactive material, a biocompatible polymer, and as a release inhibitor, an oil containing C18:1, C18:1 (OH) and C18:2 long-chain fatty acids, and resolves problems such as side effects, caused by initial over-release, by having remarkable release characteristics of increased incorporation rate of the bioactive material and minimization of initial over-release since the release inhibitor encompasses the bioactive material-incorporated biocompatible polymer one more time; and a preparation method therefor. La présente invention concerne une microsphère à libération prolongée à long terme contenant un matériau bioactif, et son procédé de préparation, et concerne : une microsphère à libération prolongée à long terme, qui comprend un matériau bioactif, un polymère biocompatible et, en tant qu'inhibiteur de libération, une huile contenant des acides gras à chaîne longue C18 : 1, C18 : 1 (OH) et C18 : 2, et résout des problèmes tels que des effets secondaires, causés par une libération initiale excessive, au moyen de caractéristiques de libération remarquables de taux d'incorporation accru du matériau bioactif et de la réduction au minimum de la libération excessive initiale étant donné que l'inhibiteur de libération entoure le polymère biocompatible incorporé dans un matériau bioactif une fois de plus ; et son procédé de préparation. 본 발명은 생리활성물질을 함유하는 장기 서방출성 마이크로스피어 및 이의 제조방법에 관한 것으로, 생리활성물질, 생체적합성 고분자 및 방출억제제로 C18:1, C18:1 (OH) 과 C18:2의 장쇄 지방산을 함유하는 오일류를 포함하되, 상기 방출억제제가 생리활성물질이 봉입된 생체적합성 고분자를 한번 더 둘러싸는 것으로 인해 생리활성물질의 봉입률이 증가하고 초기 과다방출이 최소한으로 억제되는 탁월한 방출특성을 가지고 있어, 초기 과다방출로 인한 부작용등의 문제점이 해소된 장기 서방출성 마이크로스피어 및 이의 제조 방법을 제공한다.