PIMAVANSERIN SALTS USEFUL FOR THE PRODUCTION OF A PHARMACEUTICAL PREPARATION

• Main Authors: VARGA, Zoltán, NAGY, Tamás, RÁCZ, Norbert, MOLNÁRNÉ SAMU, Erika, KÁTAINÉ FADGYAS, Katalin, TÓTHNÉ LAURITZ, Mária, VOLK, Balázs, DIETRICH, Ádám Dezső, KESZTHELYI, Adrienn, SZLÁVIK, László
• Format: Patent
• Language: English; French
• Published: 11.01.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The object of the present invention relates to the formula (1) 1-(4-fluorobenzyl)-1-(1- methylpiperidin-4-yl)-3-[4-(2-methylpropoxy)benzyl]carbamide (pimavanserin) besylate, cyclamate, tosylate, benzoate and mandelate salts, as well as to their amorphous and crystalline forms, their hydrates and solvates, to the production of these salts, and to pharmaceutical preparations containing these, as well as to the therapeutic use of these salts. L'objet de la présente invention porte sur la formule (1) 1- (4-fluorobenzyl)-1-(1-méthylpipéridin-4-yl)-3-[4- (2-méthylpropoxy) benzyl] carbamide (pimavansérine) le bésylate, le cyclamate, le tosylate, le benzoate et les sels de mandelate, ainsi que sur leurs formes amorphes et cristallines, leurs hydrates et leurs solvates, sur la production de ces sels, sur des préparations pharmaceutiques les contenant, ainsi que sur leur utilisation thérapeutique.