NOVEL IMMUNOGENIC FORMULATIONS COMPRISING LINEAR OR BRANCHED POLYACRYLIC ACID POLYMER ADJUVANTS

The present invention provides for novel immunological and vaccine formulations comprising a newly applied non-crosslinked polyacrylic acid polymer adjuvant. The adjuvants may be combined with a wide variety of immunogens to produce vaccines that are safe and effective when administered to a wide ra...

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Main Authors PROBECK-QUELLECT, Patricia, HAENSLER, Jean, DE LUCA, Karelle, TALAGA, Philippe, REMOLUE, Lydie, GARINOT, Marie, RIGAUT, Guillaume, CHAMBON, Véronique, COTTE, Jean-Francois, PARISOT, Alexis, Guy, André, Lucien, ANDREONI, Christine, Michele, Pierrette
Format Patent
LanguageEnglish
French
Published 21.12.2017
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:The present invention provides for novel immunological and vaccine formulations comprising a newly applied non-crosslinked polyacrylic acid polymer adjuvant. The adjuvants may be combined with a wide variety of immunogens to produce vaccines that are safe and effective when administered to a wide range of target animals. The immunogens may include, but are not limited to: inactivated pathogens, attenuated pathogens, subunits, recombinant expression vectors, plasmids or combinations thereof. The animals may include, but are not limited to: humans, murine, canines, felines, equines, porcines, ovines, caprines and bovines. La présente invention concerne de nouvelles formulations immunologiques et vaccinales comprenant un adjuvant polymère d'acide polyacrylique non réticulé nouvellement appliqué. Les adjuvants peuvent être combinés à une grande variété d'immunogènes pour produire des vaccins qui sont sûrs et efficaces lorsqu'ils sont administrés à un large éventail d'animaux cibles. Les immunogènes peuvent comprendre, mais sans s'y limiter : des agents pathogènes inactivés, des agents pathogènes atténués, des sous-unités, des vecteurs d'expression recombinés, des plasmides ou des combinaisons de ces derniers. Les animaux peuvent comprendre, mais sans s'y limiter : des humains, des souris, des chiens, des félins, des équidés, des porcins, des ovins, des caprins et des bovins.
Bibliography:Application Number: WO2017US37745